Molecular Formula | C11H12N2 |
Molar Mass | 172.23 |
Density | 1.105 g/mL at 25 °C (lit.) |
Melting Point | 57°C |
Boling Point | 125-127 °C/3 mmHg (lit.) |
Flash Point | >230°F |
Water Solubility | insoluble |
Vapor Presure | 4.05E-05mmHg at 25°C |
pKa | 7.54±0.31(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | n20/D 1.5645(lit.) |
Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
RTECS | NI7722500 |
HS Code | 29332900 |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
Overview | 1-benzyl-2-methylimidazole is a heterocyclic organic compound used as a raw material for organic synthesis. |
Preparation | 1-benzyl-2-methylimidazole was prepared as follows: Under nitrogen atmosphere, 8.2g(0.1 mol) of 2-methylimidazole was added to a slurry of 2.4g(0.1 mol) of sodium hydride in 50ml of dimethylformamide under stirring. A slow exothermic reaction occurs and the temperature reaches 43°C. When the exotherm subsided, the reaction was heated to 70 °-75°C on a steam bath for half an hour, and then at 95°C for 15 minutes to complete the reaction, as evidenced by the cessation of the evolution of the gas. It was then cooled to 68°C and 12.7g(0.1 mol) of benzyl chloride was added dropwise. An exothermic reaction occurs and the temperature reaches 95°C. After stirring for half an hour after adding, the reaction was poured into 600ml of water, and the product was extracted with ethyl acetate (2 × 200ml). The combined extract was sequentially washed with water (1 × 400ml), saturated aqueous sodium chloride solution (1 × 100ml), and then washed with 6NHCl(1 × 50ml). The HCl wash was extracted with ether (1 × 25ml) and then made alkaline by adding sodium hydroxide. The separated yellow oil was extracted into ether, the extract was dried (MgSO4) and evaporated under reduced pressure to give the light yellow oil 1-benzyl-2-methylimidazole. The yield is 11.5g(60.5%). |